Estradiol (E₂) at dose of 30 mg/kg was implanted in back muscle of cultured female Chinese Sturgeon(Acipenser sinensis)(age: 11 years old; average body weight: 46 kg). Serum was sampled from the tail of fish before implantation and 30 days, 120 days and 200 days after implantation. The serum concentrations of total protein (TP), albumin (ALB), globulin (GLB), triglyceides (TG), total cholesterol (TCH), glucose (GLU), vitellogenin (VTG) were measured. The results showed that the concentrations of TP, ALB, GLB, TG, TCH, VTG, except for GLU, in serum in the treated group were significantly higher than those in control group. These preliminary data are useful for searching for the exogenous substance to accelerate ovarian development of Chinese Sturgeon.