White-nose syndrome (WNS), an infectious disease outbreaking in 2006 drove a large amount of bat species to face the threat of death. Some studies show that WNS is caused by psychrophilic fungus, Pseudogymnoascus destructans, which leads to a series of aberrant behaviors of hibernating bats by invading cutaneous tissues. These aberrant behaviors in turn cause rapid depletion of limited fat and energy stores, as well as death of infected bats. In this paper, we review the studies on disease symptom, transmission rule, pathogenesis and immune genetic response and suggest some directions of future researches in this field.