The structural characteristics of the skin and fins were observed by paraffin section, haematoxylin-eosin and Alcian blue-periodie acid Schiff staining in Catfish-like Loach (Triplophysa siluroides). Skin samples were taken from head, abdomen, dorsal, lateral and caudal peduncle, respectively, and fins samples were taken from pectoral fin, ventral fin, dorsal fin, anal fin and caudal fin. The comparison of difference between groups was analyzed with one-way ANNVOA method using SPSS 17.0. The results showed that the skins were all composed of epidermis and dermis, and the latter was divided into stratum spongiosum and stratum compactum (PlateⅠ). Different parts of skins had different thicknesses which was related to the size of the glands (Table 1, Table 2). Among the five different positions, the thickest epidermis layer (84.62 ± 10.82 μm) was present in the abdomen, while the thinnest epidermis (14.97 ± 3.95 μm) was present in lateral region, and there was significant difference in epidermis thickness at different positions (Table 1). Mucous cells, club cells and taste buds were observed in the epidermis layer. For stratum spongiosum, the thickest layer (282.71 ± 70.56 μm) was in the head, while the thinnest layer (29.07 ± 4.88 μm) was in the caudal peduncle (Table 1). There were some pigment cells, vacuolar cells and granular glands in the stratum spongiosum, and the mucous glands were present in the stratum compactum (PlateⅠ). The thickness of stratum spongiosum could be thicker due to the presence of glands. Fins were composed of epidermis layer, collagen fiber layer, sub-collagen fiber layer and fin ray. The composition of epidermis layer was similar with that in the skin. Fin ray was mineralized connective tissue (PlateⅠ).