[Objectives] This study aims to study the regulatory role of exosomes derived from Bactrian Camel Camelus bactrianus plasma in the invasion and metastasis of hepatocellular carcinoma cells. [Methods] In this study, the plasma exosomes of Bactrian Camels were separated by ultracentrifugation, the morphology and ultrastructure of the exosomes were observed by transmission electron microscopy, and the particle size and distribution of the exosomes were determined by nanoparticle tracking analyzer, the exosomes were co-cultured with hepatoma cells (MHCC-97H and Huh7 cells) after labeling with fluorescent dye PKH67, and the uptake of plasma-derived exosomes by hepatoma cells was observed by scanning confocal microscopy (LSCM). [Results] The obtained plasma exosomes of Bactrian Camels were all cup-shaped or round-shaped, with a diameter of about 100 nm (Fig. 1):the main peaks of particle size were about 124.6 nm and 117.9 nm, respectively, and the overall size distribution ranged from 50 nm to 200 nm (Fig. 2). Exosomes carrying PKH67 markers were observed to enter MHCC-97H and Huh7 cells under LSCM, and mainly distributed in the cytoplasm of cell membranes and perinucleus (Fig. 3). [Conclusion] In this study, exosomes derived from Bactrian Camel plasma were successfully extracted, and the uptake of exosomes by hepatoma cells was observed, suggesting that hepatocellular carcinoma cells may be one of the target cells of Bactrian exosomes.