The distribution and density of endocrine cells in the digestive tract of Takydromus wolteri were studied by the method of ABC (avidin-biotin complex method) immunohistochemical technique with six gut hormone antisera.5-HT cells distributed throughout the digestive tract from esophagus to rectum,with the highest density in the pylorus.The other five kinds of endocrine cells did not distribute as widely as the 5-HT cells.SS cells were not detected in the esophagus,ileum and rectum.The density of SS cells was the highest in the pylorus,followed by stomach part,and they were rarely observed in small intestine.Gas cells and PP cells distributed in small intestine,with the highest density in the duodenum.The distribution density of Glu cells was the highest in the pyloricus,followed by duodenum and jejunum,the lowest in the ileum.SP cells were only found in the pylorus.The six kinds of endocrine cells were mainly in round shape and shuttled shape.They widely lied between epithelial cells,between glandular epithelial cells and at the bottom of epithelia.The distribution density of endocrine cells was related to its feeding habit,food component and living environment.And morphologies of endocrine cells were conformable with the endocrine and exocrine functions.