Distribution patterns of six kinds of endocrine cells, i.e. cells secreting 5-hydroxtryptamine (5-HT), gastrin (Gas), somatostatin (SS), slucagon (Glu), pancreatic polypeptide (PP) and substance P (SP), in the digestive tract of Salamandrella keyserlingii were investigated using the avidin-biotin-peroxidase complex (ABC) immunohistochemical method. Statistical analysis of distribution density of endocrine cells in the digestive tract was conducted following Duncan methods. The results showed that 5-HT cells were distributed in all parts of the digestive tract, with the highest density in gastric body (2.80 ± 0.70) and duodenum (2.60 ± 0.75), but the lowest in the pylorus (0.85 ± 0.67); Gas cells were merely distributed in small intestine with their highest density distributed in duodenum (1.85 ± 0.75); SS cells were distributed in the esophagus, stomach body, pylorus, duodenum and ileum, with their highest density distributed in pylorus (2.25 ± 0.64); Glu cells were merely found in gastric cardia and gastric body; PP and SP cells were not detected in the whole digestive tract (Table 2). The shapes of various endocrine cells were round, oval, cone-shaped and fusiform (PlateⅠ). The density distribution and morphology of endocrine cells in the digestive tract were similar to those of Salamandrella keyserlingii and other amphibians inhabited in Heilongjiang province, yet unique characteristics of S. keyserlingii existed, and the reason of which may be due to factors such as food sources and habitats.