Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs), which may replace embryonic stem cells (ESCs) and have great application potential in drug screening, regenerative medicine, etc. Since the iPSCs development by retroviral transduction of a defined set of transcription factors into fibroblasts (mF) was first reported in 2006 in mouse (Mus musculus), more new strategies have been developed to improve and refine the reprogramming technology. Recent technology of RNAs-mediated iPSCs becomes an emerging research hotspot which provides an optimism for the generation of safe iPSCs without any genomic modification. RNAs-mediated iPSCs technology includes the application of modified mRNAs, miRNAs, siRNAs and lncRNAs. In this paper, the research progress of various RNAs-mediated iPSCs technologies are reviewed, including the advantages, deficiencies and the improvement of these techniques, so as to provide references for the development and application of iPSCs technology.