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余航,叶亚琼,赵海全,张晖.2021.动物特络细胞的研究进展.动物学杂志,56(5):791-799.
动物特络细胞的研究进展
Advances in Research on Telocyte of Animals
投稿时间:2021-01-04  修订日期:2021-08-31
DOI:10.13859/j.cjz.202105017
中文关键词:  特络细胞  间质细胞  免疫表型  超微结构  生理功能
英文关键词:Telocyte  Interstitial cells  Immunophenotype  Ultrastructure  Physiological function
基金项目:国家自然科学基金项目(No. 31760716,31560681),江西省科技计划项目(No. 20151BBF60007,20171ACB21028)
作者单位E-mail
余航 佛山科学技术学院生命科学与工程学院 佛山 528231 907319977@qq.com 
叶亚琼 佛山科学技术学院生命科学与工程学院 佛山 528231 cn874462@163.com 
赵海全 佛山科学技术学院生命科学与工程学院 佛山 528231 fszhaohq@163.com 
张晖 佛山科学技术学院生命科学与工程学院 佛山 528231江西农业大学动物科学技术学院 南昌 330045 zhanghui429@hotmail.com 
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中文摘要:
      特络细胞是一种新型间质细胞,其最显著的形态特征是具有极其细长且粗细不均而呈念珠形的细胞突起,可以和周围的同/异型细胞、血管、神经末梢等形成细胞连接。特络细胞还可释放细胞外囊泡(EVs)和其他信号分子,从而发挥其潜在的生理功能。先前的研究表明,特络细胞的功能与动物组织再生有关,因此对于低等动物特络细胞的研究有助于进一步理解其参与组织再生的机理,为人类再生医学提供参考。本文综述了近年来有关特络细胞在不同动物器官组织中的分布位置、免疫表型、超微结构特点、与周围细胞型的结构关系以及特络细胞功能的研究进展,探讨了已有研究中不同动物组织器官中特络细胞在超微结构上的差异,有助于进一步理解特络细胞的生物学特性与生理功能。
英文摘要:
      Telocytes are a new type of interstitial cells. The most prominent morphological feature of telocytes is their very long and thin moniliform cellular prolongations with uneven thickness (telopodes) that can form cellular connections with surrounding homologous/heterogenous cells, blood vessels, and nerve endings. Telocytes are able to release extracellular vesicles and signal molecules, thus to exert their potential physiological functions. Previous studies have shown that the function of telocytes is related to the tissue regeneration in animals, therefore, the researches on telocytes in lower animals can help to further understand the mechanism of how telocytes participate in tissue regeneration and provide insights into human regenerative medicine. This review article summarizes the recent advances in researches on telocytes including their organ loeations, immunophenotypes, ultrastructural characteristics, structural relationships with surrounding cells, and functions in different animal species. The ultrastructure differences of telocytes in tissues and organs of different animals are also discussed. This review aims to help researchers further understand the biological characteristics and potential physiological functions of telocytes.
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