| 顾浩宇,黄章龙,罗海玻,宋凤.2023.哺乳动物同性生殖研究历程及应用前景.动物学杂志,58(5):790-799. |
| 哺乳动物同性生殖研究历程及应用前景 |
| Research History and Application Prospects of Same-Sex Reproduction in Mammals |
| 投稿时间：2023-02-16 |
| DOI：10.13859/j.cjz.202305013 |
| 中文关键词: 同性生殖 孤雌生殖 孤雄生殖 |
| 英文关键词:Same-sex reproduction Parthenogenesis Androgenesis |
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| 中文摘要: |
| 繁殖是所有生命形式的基础，同性生殖作为一种特殊的繁殖方式存在于自然界中。同性生殖包含孤雌生殖和孤雄生殖，在哺乳动物中尚未被发现。印记基因等表观遗传机制的存在阻碍了同性生殖胚胎发育。目前利用基因编辑已成功培育出双母系小鼠(Mus musculus domesticus)、单母小鼠和双父系小鼠，双母系小鼠和单母小鼠可正常发育并繁殖后代，双父系小鼠可存活48 h。本文综述了哺乳动物同性生殖相关技术以及探究历程，总结了同性生殖技术的应用前景与发展方向。 |
| 英文摘要: |
| Reproduction is the basis of all forms of life, and same-sex reproduction exists in nature as a specific form of reproduction. Same-sex reproduction consists of both parthenogenesis and androgenesis and has not yet been discovered in mammals. The presence of epigenetic mechanisms such as imprinted genes hinders the development of same-sex reproductive embryos. The paternally expressed imprinted genes promote embryonic growth, while maternally expressed imprinted genes inhibit embryonic growth, and same-sex reproduction expresses only one side of the imprinted gene, resulting in overgrown or undeveloped embryos. The knockout of some of the imprinted genes using embryonic stem cell technology has been successful in producing bimaternal and bipaternal mice, and single maternal mice using methylation modifications. This paper reviews the technology and history of mammalian same-sex reproduction, summarizes its potential applications and directions, and analyses its possible advantages in animal husbandry research, genetics research, and disease model construction and treatment. |
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