| 向伟,谢伟伟,张宝云,康岳华,朱圣琳,蒋嘉靖,吕亚慧,储明星,王凭青.2014.神经激肽B对哺乳动物GnRH脉冲发生器的调节.动物学杂志,49(4):621-629. |
| 神经激肽B对哺乳动物GnRH脉冲发生器的调节 |
| Effects of Neurokinkin B on Reproductive Function in Mammals |
| 投稿时间：2013-09-27 修订日期：2014-05-05 |
| DOI：10.13859/j.cjz.201404021 |
| 中文关键词: 神经激肽B 生殖功能 促性腺激素释放激素脉冲发生器 性激素 性别二态性 |
| 英文关键词:Neurokinkin B (NKB) Reproductive function Gonadotropin-releasing hormone pulse generator Steroid hormone Sexual dimorphism |
| 基金项目:国家自然科学基金面上项目(No. 31372287)，中国农业科学院科技创新工程项目(No. cxgc-ias-13-2014)，国家大学生创新性实验计划项目(No. 1210611062)，中央高校基本科研业务费(No. CDJXS12230002) |
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| 中文摘要: |
| 哺乳动物的生殖功能受体内状态和外部环境综合作用的影响,这种综合作用通过错综复杂的神经内分泌系统最终汇集于GnRH系统从而影响HPG轴的状态。NKB目前被认为是除kisspeptin外,调控GnRH脉冲分泌的又一关键因子。大量研究证实,NKB能够影响GnRH和LH的分泌,进而影响青春期的启动和生殖功能。然而,NKB对LH分泌的影响是刺激作用还是抑制作用尚存在争论。此外,NKB如何作用于GnRH神经元的信号通路尚不清楚,或性激素是否参与这一生理过程，是目前的研究热点问题之一。文章就NKB及其受体的分布、神经网络结构、NKB对GnRH脉冲发生器的作用进行了系统的阐述,并针对目前尚待解决的一些问题进行了探讨。 |
| 英文摘要: |
| The hypothalamo-pituitary-gonadal (HPG) axis integrates internal and external cues via intricate network of neuroendocrine systems that, ultimately acting on gonadotropin-releasing hormone (GnRH) system, to regulate reproductive function in mammals. To date, neurokinkin B is proposed as a critical factor on modulating pulsatile GnRH secretion as well as kisspeptin. A large number of previous studies have confirmed that neurokinkin B suppresses GnRH system and luteinizing hormone (LH) secretion, thereby affecting the onset of puberty and reproduction. However, whether the stimulation or inhibition of LH secretion by NKB remains controversial. In addition, the signaling pathway how NKB acting on GnRH neurons is not clear or whether steroid hormone participate in this Physiological processes, which is currently a subject of intense research in the field. The distribution and bilateral network of NKB and NK3R, as well as effects of NKB on GnRH pulse generator, are systematically elaborated and the remaining unsolved problems are also discussed in this paper. |
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